Scientific scientific studies of promethazine hydrochloride and codeine phosphate syrup did not incorporate adequate numbers of subjects aged 65 and in excess of to find out whether they answer in different ways from youthful topics. Other noted clinical experience hasn't identified distinctions in responses involving the aged and young patients.
To decreased your hazard, your medical professional should have you go ahead and take smallest dose that works, and consider it for the shortest feasible time. See also How to Use section For more info about dependancy.
It's tricky to identify what constitutes a typical toxic or lethal dose. Nonetheless, the lethal oral dose of codeine within an Grownup is claimed to become inside the variety of 0.
Resuscitation may very well be needed (see OVERDOSAGE). Restricted details recommend that usage of promethazine hydrochloride during labor and shipping doesn't have an appreciable impact on the length of labor or supply and isn't going to improve the danger of want for intervention from the new child.
Discuss with your care staff about using this medication in little ones. This medication is not really authorized to be used in young children.
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This medication has been prescribed for your present problem only. Usually do not utilize it afterwards for another problem Unless of course instructed to do so by your medical doctor. A unique medication may very well be required in All those conditions.
Excessively significant dosages of antihistamines, such as promethazine hydrochloride, in pediatric sufferers may bring about unexpected death (see OVERDOSAGE). Hallucinations and convulsions have occurred with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. In pediatric individuals that are acutely sick associated with dehydration, There's a heightened susceptibility to dystonias with the use of promethazine HCl.
Utilizing Alcoholic Promethazine codeine syrup beverages or tobacco with selected medicines could also trigger interactions to occur. The next interactions are actually chosen on The premise of their likely significance and therefore are not essentially all-inclusive.
Codeine: Dosage of codeine Shouldn't be Elevated if cough fails to reply; an unresponsive cough ought to be reevaluated in five days or faster for possible underlying pathology, like overseas physique or reduced respiratory tract ailment.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients less than 6 many years of age, simply because The mixture could cause fatal respiratory depression In this particular age inhabitants.
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e., numerous copies from the gene for cytochrome P450 isoenzyme CYP2D6 or large morphine concentrations). These small children may be significantly sensitive for the respiratory depressant consequences of codeine that's been promptly metabolized to morphine. Codeine is contraindicated for write-up-operative soreness management in these people (see WARNINGS – Loss of life Associated with Extremely-Swift Metabolism of Codeine to Morphine and CONTRAINDICATIONS). The mixture of promethazine hydrochloride and codeine phosphate need to be utilised with caution in pediatric sufferers 6 decades and more mature (see WARNINGS - Use in Pediatric Patients).
Due to the fact recurrences of NMS happen to be documented with phenothiazines, the reintroduction of promethazine HCl should be carefully thought of.